Z-3578 - CAS 473687-20-6

Z-3578 is a small molecule antagonist targeting the MrgX2 (Mas-related G protein-coupled receptor X2) with notable anti-pseudoallergic properties, exhibiting a KD value of 729 nM. It effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, with IC50 values of 4.90 μM and 6.18 μM, respectively, suppresses the release of β-hexosaminidase, and significantly reduces the release of histamine and TNF-α, as well as intracellular calcium flux. Additionally, in a mouse pseudoallergy model, Z-3578 significantly alleviates foot swelling, dye leakage, and reduces serum histamine levels, indicating a strong in vivo anti-allergic effect. Z-3578 presents as a promising lead compound in the field of anti-allergic treatments, particularly for pseudoallergic reactions.

MRGPR, TNF

GPCR/G Protein, Apoptosis

473661

C23H16Cl2N4OS

467.37

O=C(NC1=CC=C(Cl)C=C1Cl)CSC=2N=NC(C3=CC=CC=C3)=C(N2)C=4C=CC=CC4

-20°C

Ice Packs

Small Compound