Z-Gly-Pro-Phe-Leu-CHO - CAS 159659-05-9

Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a selective and potent proteasome inhibitor, with inhibition constants (Ki) of 1.5 μM for branched-chain amino acid-preferred, 2.3 μM for small neutral amino acid-preferred, and 40.5 μM for chymotrypsin-like activities, and an inhibitory concentration (IC50) of 3.1 μM for peptidyl-glutamyl peptide hydrolyzing activity [1].

Proteasome

Proteases/Proteasome, Ubiquitination

159659-05-9

C30H38N4O6

550.65

C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C=O)=O)(=O)[C@H]2N(C(CNC(OCC3=CC=CC=C3)=O)=O)CCC2

-20°C

Ice Packs

Peptide