(Z) -RG-13022 - CAS 149286-90-8

(Z) -RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E) -RG-13022 (IC50 = 38 μM) . This compound is applied in breast cancer cell research [1] [2].

Others, EGFR

Others, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

149286-90-8

C16H14N2O2

266.29

C(=C(\C#N)/C=1C=CC=NC1)\C2=CC(OC)=C(OC)C=C2

-20°C

Ice Packs

Small Compound