Z-VAE (OMe) -fmk - CAS 1027141-02-1

Z-VAE (OMe) -fmk is a cell-permeable and irreversible UCHL1 inhibitor. The inhibitor approaches the active-site cleft from the opposite side of the crossover loop as compared to the direction of approach of ubiquitin's C-terminal tail, thereby occupying the P1' (leaving group) site, a binding site perhaps used by the unknown C-terminal extension of ubiquitin in the actual in vivo substrate (s) of UCHL1.

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1027141-02-1

C23H32FN3O7

481.51

[C@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)[C@@H](C)C)=O)C)=O)(CCC(OC)=O)C(CF)=O

-20°C

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