Z21115 - CAS 2958668-54-5

Z21115 is an orally effective phosphodiesterase 4 (PDE4) inhibitor that can inhibit PDE4D7 with an IC50 of 10.5 nM. It suppresses the expression of IL-6, TNF-α, and iNOS induced by Lipopolysaccharide. In a DSS-induced mouse colitis model, Z21115 demonstrates anti-inflammatory activity without significant toxicity at doses up to 1 g/kg.

PDE

Metabolism

2958668-54-5

C20H20F2N2O4

390.38

FC(F)OC1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)C3=CN(N=C13)C4CC4

-20°C

Ice Packs

Small Compound