Z218484536 - CAS 1223877-07-3

Z218484536 is a selective phosphoserine phosphatase (PSPH) inhibitor that can penetrate the blood-brain barrier. It binds to PSPH with an affinity (Kd) of approximately 0.23 μM. By doing so, Z218484536 reduces levels of L-serine and D-serine in astrocytes. It also inhibits spontaneous seizures without causing significant side effects and demonstrates effective antiepileptic properties in the temporal lobe epilepsy (TLE) model.

Phosphatase

Metabolism

1223877-07-3

C11H10FN5O

247.23

O=C(N)NN=CC1=CNN=C1C=2C=CC(F)=CC2

-20°C

Ice Packs

Small Compound