Z57346765 - CAS 1016340-64-9

Z57346765 is a specific PGK1 (Phosphoglycerate kinase 1) inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis. In the clinical phase, Z57346765 had a dose-dependent inhibitory effect on locally advanced renal clear cell carcinoma (KIRC) by inducing changes in the expression of genes related to cell metabolism, DNA replication, and the cell cycle.

Others, PGK1

Others, Metabolism

1016340-64-9

0.9985

C17H18N4O

294.35

OCCNC=1N=C(N=C2C=CC=CC21)NC3=CC=C(C=C3)C

-20°C

Ice Packs

Small Compound