Zanamivir-13C,15N2 - CAS 1276528-62-1

Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza.

1276465

C12H20N4O7

335.292

[H][C@]1(OC(=C[C@H](N[13C]([15NH2])=[15NH])[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO |c:3|

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