ZG297 - CAS 2999673-52-6

ZG297 is an agonist of Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. It degrades SaFtsZ and inhibits bacterial cell division, exhibiting antistaphylococcal activity by inhibiting S. aureus 8325-4 and MRSA strains, with a MIC range of 0.063-256 μg/mL. In mouse models, ZG297 demonstrates anti-infective properties.

Antibiotic, Antibacterial

Microbiology/Virology

2999615

C31H35F3N4O3

568.63

C(NCCCC(F)(F)F)(=O)N1[C@@]2(N([C@@]([C@H](CC)C)(C(=O)N(CC3=C4C(=C5C(=C3)C=CC=C5)C=CC=C4)C2)[H])C(=O)CC1)[H]

-20°C

Ice Packs

Small Compound