ZIP - CAS 863987-12-6

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

PKC

Chromatin/Epigenetic, Cytoskeletal Signaling

863969

C90H154N30O17

1928.4

C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC(CCCCCCCCCCCCC)=O)CO)=O)[C@H](CC)C)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C=2C=3C(NC2)=CC=CC3

-20°C

Ice Packs

Peptide