ZJ 43 - CAS 723331-20-2

ZJ43 is a potent inhibitor of glutamate carboxypeptidase II (K (i) = 0.8 nM) and III (K (i) = 23 nM) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models [1].

GluR, Aminopeptidase

Neuroscience, Metabolism

723309

C24H39N4O14

607.59

CC(C)C[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=[O]CC(C)C[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O

-20°C

Ice Packs

Small Compound