ZLY032 - CAS 2314465-67-1

ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay) .1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both) . ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose.

PPAR, Others

Metabolism, Others, DNA Damage/DNA Repair

2314397

C22H18F3NO4S

449.44

C(C(O)=O)[C@H]1C=2C(=CC(OCC=3SC(=NC3C)C4=CC=C(C(F)(F)F)C=C4)=CC2)OC1

-20°C

Ice Packs

Small Compound