ZLY06 - CAS 2834727-04-5

ZLY06 is a dual agonist of peroxisome proliferator-activated receptors (PPAR) δ and γ with oral activity (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM) . It mediates the upregulation of CD36 and induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1. Moreover, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, primarily by enhancing the β-oxidation of fatty acids and reducing hepatic lipid synthesis, thereby alleviating fatty liver disease.

PPAR, Akt

Cytoskeletal Signaling, DNA Damage/DNA Repair, Metabolism, PI3K/Akt/mTOR signaling

2834727-04-5

C25H26O6

422.47

O=C\1C=2C(O/C1=C\C3=CC(C)=C(OC(C(O)=O)(C)C)C(C)=C3)=CC(OCC4CC4)=CC2

-20°C

Ice Packs

Small Compound