Zoptarelin doxorubicin - CAS 139570-93-7

Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation

GNRH Receptor

GPCR/G Protein

139470

C91H117N19O26

1893.01

O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(CCCC(NCCCC[C@@H](NC([C@H](CC5=CC=C(O)C=C5)NC([C@@H](NC([C@H](CC=6C=7C(NC6)=CC=CC7)NC([C@H](CC8=CN=CN8)NC(=O)[C@H]9NC(=O)CC9)=O)=O)CO)=O)=O)C(N[C@H](C(N[C@H](C(=O)N%10[C@H](C(NCC(N)=O)=O)CCC%10)CCCNC(=N)N)=O)CC(C)C)=O)=O)=O)=O)(O)C1)[C@H]%11C[C@H](N)[C@H](O)[C@H](C)O%11

-20°C

Ice Packs

Peptide