Zotepine - CAS 26615-21-4

Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. This second-generation antipsychotic is primarily used to treat schizophrenia, and clinical trials have investigated its efficacy as an antimanic agent in patients with acute bipolar mania.

Dopamine Receptor, 5-HT Receptor, Histamine Receptor, Adrenergic Receptor

Immunology/Inflammation, Neuroscience, GPCR/G Protein

26590

0.9978

C18H18ClNOS

331.86

CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc12

-20°C

Ice Packs

Small Compound